Four years postoperatively, left supraclavicular lymph node cancer recurred. After radiotherapy, the lesion was completely relieved. Two years postoperatively, left supraclavicular lymph node metastasis occurred. After the operation, routine chemotherapy was conducted. Immunohistochemistry showed three negative expressions (ER, PR and Cerb-B2 expressions were negative). Postoperative pathologic diagnosis was invasive ductal carcinoma, and tumorous clinical stage was stage II B (T2N1M0). In 2004, she underwent modified radical mastectomy of breast cancer in our hospital. In addition, special hyperbaric chamber treatment was carried out.įemale, 54 years old. Repeated intermittent drug therapies of neurotrophic drugs such as vitamin B1, cobamamide and mecobalamine and hormone drugs were conducted. As a result, left lower extremity numbness was aggravated, and he occasionally suffered from pain. Also, physiological responses existed, and no pathological reaction was reflected.Īfterwards, he received chemotherapy. Myodynamic examination showed that bilateral muscle forces were of grade V and pain sense slightly reduced. After one month following completion of radiotherapy, the patient gradually presented left lower extremity numbness, without pain or fever. As the radiation damage of the patient’s local skin was severe and radiation proctitis appeared, the radiotherapy was suspended for 2 weeks and then continued: pelvic anterior and posterior fields, 10 MV X-ray and 12 Gy dose. After operation, the adjuvant radiotherapy was carried out: three-field pelvic radiotherapy, 10 MV X-ray and 30 Gy cumulative dose for 21 days. In the local hospital, radical resection of rectal carcinoma was carried out, and the clinical stage was stage III C. In 2005, enteroscheocele was conducted due to hemafecia to find rectal occupying lesions, and its pathologic diagnosis was rectal carcinoma. Aim of the studyThis study analyzes peripheral nerve radiation damage in two cases of patients with cancer (rectal cancer and breast cancer) after radiotherapy at the corresponding sites in clinical practice and summarizes experiences and lesions by a retrospective analysis in order to provide a reference for future tumor radiotherapy. Among the surviving patients, the percentage of patients with brachial plexus damage caused by radiotherapy was 89%, and the percentage of patients with upper extremity paresis was 83%. After 34-year follow-up, the incidence rate was 63%. Johnsson reported brachial plexus damage of 71 cases of patients after radiotherapy following complete breast hysterectomy, and the main clinical manifestations included upper extremity pain, weakness, sensation loss and paralysis and upper extremity paresis. A number of cases of radiotherapy-caused peripheral nerve damage have been reported. Secondly, for patients with rectal cancer, radiotherapy after urogenital tumorectomy will cause lumbosacral plexus injury. For patients with breast cancer and head and neck tumor, radiotherapy will cause brachial plexus damage. Radiotherapy-caused peripheral nerve damage mainly occurs at two large positions. At present, there is still no effective treatment method, and it is an important problem in the field of radiotherapy. Radiotherapy-caused damage will cause a great pain to patients, and radioactive nerve damage is one kind of radiotherapy-caused damage. Meanwhile, side effects correspondingly decrease and ease, but occur occasionally. The comprehensive application of multiple treatment methods greatly enhances tumor treatment efficiency, prolongs the survival time of patients and improves patients’ life quality. IntroductionWith the rapid development of tumor therapeutics, antineoplastic measures are increasing.
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